临床表现 临床表现
Jennifer A Frontera1, Arjun V Masurkar1,2,3, Alok Vedvyas1,2,3
1NYU Grossman School of Medicine, New York, NY, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
与没有长期COVID症状的患者相比,长期COVID患者的认知功能明显恶化,轻度认知障碍 (MCI) 的比率更高,包括阿尔茨海默氏症类型. 这突显了SARS-CoV-2感染对神经系统的持续影响.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 老年学是指老年学的学科.
背景情况:
- 有限的数据存在,比较长期COVID患者与对照者的神经精神病学结果.
- 调查认知差异对于了解长期COVID-19后果至关重要.
研究的目的:
- 为了比较长期COVID和没有COVID的患者的神经心理检测结果.
- 确定长期COVID和认知障碍诊断之间的关联.
主要方法:
- 横截面研究比较COVID-19阳性 (COV+) 和阴性 (COV-) 患者.
- 使用西印度群岛大学痴呆症查尺度3 (UDS3) 进行神经精神病学测试.
- 医生共识诊断 (正常,MCI,痴呆症) 被盲目的长期COVID状态.
主要成果:
- 长期COVID患者的认知测试结果明显差 (64%vs. 46%) 和CDR得分更高 (26%vs. 6%).
- 25%的长期COVID患者接受了MCI或痴呆症诊断,而没有长期COVID的患者则为6%.
- 长期COVID与MCI的几率增加有关,特别是阿尔茨海默氏症类型的MCI (aOR 4.4).
结论:
- 长期COVID与较差的认知表现和轻度认知障碍的增加率有关.
- 阿尔茨海默氏症类型的MCI在经历长期COVID症状的个体中明显更为普遍.
- 需要进一步的研究来阐明长期COVID相关认知衰退背后的机制.
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