临床表现 临床表现
Monica Sanches Yassuda1, Luc A Crivelli2, Claudia Kimie Suemoto3
1Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
认知功能指数 (CFI) 可以帮助识别拉丁美洲主观认知衰退 (SCD) 患者. 这种工具显示了早期认知障碍检测在痴呆症预防工作中的潜力.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 主观认知衰退 (SCD) 是一种自我认知的认知障碍,在标准测试中并不明显.
- 认知功能指数 (CFI) 是一种识别SCD个体的工具.
- 在拉丁美洲 (LA),对CFI的研究有限.
研究的目的:
- 研究LA人口中CFI分数和全球认知之间的关联.
- 确定CFI分数是否可以识别具有认知表现低于平均值1.0标准偏差 (SD) 的个体.
主要方法:
- 来自LatAm-FINGERS痴呆症预防研究的815名参与者的分析.
- 使用临床前阿尔茨海默氏症认知组合 (PACC-5) 评估的认知能力.
- CFI分数与PACC-5分数相关;进行了接收器操作特征 (ROC) 分析.
主要成果:
- 在CFI和PACC-5分数之间发现了显著的负相关性 (r = -0.27,p < 0.001).
- ROC分析显示,CFI的曲线下面面积 (AUC) 为0.71,用于识别具有PACC-5分数低于1 SD的个体.
- 建议最优的CFI截止分数为0.36.
结论:
- CFI可以作为认知查协议的宝贵补充,用于识别需要进一步评估的个人.
- 将CFI整合到LA的查策略中可能有助于减少认知健康差异.
- 这种方法可以推进针对LA面临的挑战而定制的痴呆症预防计划.
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