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临床表现 临床表现

Sara Becker1,2, Baeleigh VanderZwaag3,4, Hawra Al-Khaz'Alya1,2

  • 1University of Calgary, Calgary, AB, Canada.

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概括

这项研究没有发现儿童注意力缺陷/多动障碍 (ADHD) 症状在患有帕金森病 (PD) 的老年人中更常见,或ADHD与莱维体疾病 (LBD) 有关的证据. 没有建议ADHD作为LBD的早期阶段或风险因素.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 精神病学是一个精神病学.

背景情况:

  • 新兴研究表明,成年人注意力缺陷/多动症 (ADHD) 和晚年生活中的勒维体疾病 (LBD) 之间存在联系.
  • 患有LBD的人通常在生命早期报告ADHD症状,这促使进一步调查这一关联.

研究的目的:

  • 在被诊断患有帕金森病 (PD) 的老年人中调查儿童ADHD症状的患病率.
  • 评估老年人患有多动症的LBD早期标志物.
  • 确定ADHD是否是LBD的早期指标或危险因素.

主要方法:

  • 成年参与者 (40+) 从阿尔伯塔省卡尔加里招募,包括ADHD,PD和对照组.
  • 标准化的评估包括认知测试,ADHD症状尺度 (童年症状),抑郁症库存,自主功能障碍,REM睡眠行为障碍 (RBD) 库存和嗅觉识别测试.
  • 用克鲁斯卡尔-瓦利斯H或奇平方测试分析了群体差异.

主要成果:

  • 与PD和对照组相比,ADHD组报告了显著更多的童年注意力缺失和过敏冲动症状.
  • 患有PD的参与者比ADHD和对照组表现出更高的自主功能障碍 (唾液流出,便秘) 和更差的嗅觉功能.
  • 与ADHD (22.9%) 和对照 (12.5%) 组相比,PD组 (53.1%) 的可能REM睡眠行为障碍 (RBD) 更为普遍.

结论:

  • 该研究发现,患有PD的个体中儿童期ADHD症状的患病率没有增加.
  • 没有证据表明ADHD是LBD的早期阶段或危险因素.
  • 这些发现不支持ADHD和LBD之间的病理生理联系.