Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Combined inhibition of BETs and HDACs as a potential epigenetics-based therapy for malignant rhabdoid tumor.

Cell death & disease·2026
Same author

A multi-label cascade flexible neural forest model for predicting the subcellular location of multi-site bacterial proteins.

Scientific reports·2026
Same author

Targeting DNGR-1 with Fangchinoline Elevates Dendritic Cell Antigen Cross-Presentation-Mediated Antitumor Immunity in Melanoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Extracellular vesicles of human transformed skin-derived precursors containing miR-221-3p promote hair growth through DKK2-mediated Wnt/<i>β</i>-catenin signaling.

Bioengineering & translational medicine·2026
Same author

Ameliorative effect of Polygonatum cyrtonema Hua polysaccharide on HFD/STZ-induced type 2 diabetes mice via improving gut microbiota imbalance and glucose metabolism disorder.

International journal of biological macromolecules·2026
Same author

NOTCH3 signal activation by its extracellular domain accumulation in an iPSC line newly established from a CADASIL patient.

Human cell·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
查看所有相关文章

相关实验视频

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

生物标志物 生物标志物

Jieyin Li1, Anqi Li2, Laihong Zhang1

  • 1Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

较低的血血小板衍生的生生长因子受体-β (PDGFRβ) 水平表明血脑屏障 (BBB) 损伤,并与阿尔茨海默病 (AD) 的进展有关,特别是在男性中,表明PDGFRβ是潜在的血生物标志物.

更多相关视频

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

相关实验视频

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物发现发现
  • 衰老研究研究 衰老研究

背景情况:

  • 大脑脊髓液 (CSF) 血小板衍生的生长因子受体-β (PDGFRβ) 和CSF/血蛋白比率 (Qalb) 是已确立的血脑屏障 (BBB) 损伤生物标志物.
  • 血PDGFRβ和BBB完整性之间的关系,以及与阿尔茨海默病 (AD) 的关联,仍然不清楚.

研究的目的:

  • 调查血PDGFRβ水平与BBB损伤之间的关联,由Qalb表示.
  • 为了探索血PDGFRβ与认知衰退和AD病理的相关性,在一个老龄化的中国队列中.

主要方法:

  • 在93名参与者中测量了血PDGFRβ和Qalb,其中包括脑和血样本.
  • 在正常对照组,主观认知衰退组,轻度认知障碍组和痴呆症组中,在592名参与者中进一步评估了血PDGFRβ.
  • 分析了与Aβ PET,tau PET,MRI衍生的测量和MoCA得分的关联.

主要成果:

  • 血PDGFRβ在整体队列和男性中与Qalb负相关,表明与BBB损伤的联系.
  • 与对照组相比,在轻度认知障碍和痴呆症患者中观察到较低的血PDGFRβ水平.
  • 血PDGFRβ的降低与粉样蛋白β (Aβ) 和PET沉积的增加以及较低的认知分数 (MoCA) 相关.

结论:

  • 血PDGFRβ水平降低表明血脑屏障 (BBB) 受到损害.
  • 血PDGFRβ可能作为一种潜在的外周生物标志物,用于检测和监测阿尔茨海默病 (AD) 中的BBB泄漏,特别是在男性中.