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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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接种SARS-CoV-2疫苗后的抗体度和功能随着年龄的增长而降低,在患有唐氏综合征的成人和儿童中.

Bianca M M Streng1, Lobke C M Hensen2, Eveline M Delemarre2

  • 1Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.

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PubMed
概括

与健康对照人群相比,患有唐氏综合征 (DS) 的人在接种COVID-19疫苗后显示抗体反应和中和减少. 疫苗在DS中的有效性取决于年龄,因此需要量身定制的免疫战略.

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抗体是对抗体的一种.唐氏综合征是什么意思 唐氏综合征免疫反应的免疫反应.接种SARS-CoV-2疫苗的方法

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科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学
  • 遗传学 是一个遗传学.

背景情况:

  • 唐氏综合征 (DS) 患者表现出免疫系统的改变,导致对像SARS-CoV-2这样的感染的易感性增加.
  • 之前的研究表明,在DS的成年人中,初级SARS-CoV-2疫苗接种后抗体水平降低.
  • 这项研究前性地检查了在儿童和成年人患有DS的COVID-19疫苗接种后的抗体反应和功能.

研究的目的:

  • 在唐氏综合征 (DS) 患者和健康对照者 (HC) 接种SARS-CoV-2初级和强剂疫苗后评估和比较抗体度和中和标位.
  • 研究DS患者年龄对疫苗反应的影响.
  • 为了确定DS中疫苗反应缺陷是否在不同类型的疫苗 (mRNA和基于载体) 中一致.

主要方法:

  • 疫苗接种后测量抗S和抗RBD抗体度和病毒中和标位 (ID50) 的前性研究.
  • 参与者包括成年人 (N=215 DS,N=93 HC) 和患有DS的儿童,接受mRNA或基于载体的初级疫苗和mRNA增强剂.
  • 在DS和HC组之间比较了抗体水平和中和能力,并在DS队列中分析了与年龄相关的趋势.

主要成果:

  • 所有参与者都显示疫苗接种后抗体度增加,但DS患者的抗S和抗RBD抗体水平始终低于HC,不论主要疫苗类型.
  • 在DS组中,抗S抗体度随着年龄的增长而下降;青少年 (12-17岁) 的水平最高,而较小的儿童 (<12岁) 的水平明显较低.
  • 血清中和在mRNA和基于载体的初级疫苗接种后,与HC相比,DS的成年人血清中和明显较低.

结论:

  • 这是第一个针对唐氏综合征 (DS) 的疫苗免疫学研究,包括儿童和成人.
  • 与健康对照人群相比,患有DS的人在接受SARS-CoV-2初级和强剂疫苗接种后,抗体度和血清中和性降低.
  • 在DS中观察到的疫苗反应缺陷是年龄相关的,这强调了在这个人群中需要特定年龄的免疫策略.