生物标志物 生物标志物
1Jeju national University hospital School of medicine, Jeju-si, Korea, Republic of (South).
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
白质过强度 (WMH) 与阿尔茨海默病 (AD) 风险和认知能力下降有关. 在AD患者中,心室附近的特定WMH位置会影响执行功能和记忆.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年病的医生 老年病的医生
背景情况:
- 白质高强度 (WMH) 在老年人中普遍存在,并与阿尔茨海默氏症 (AD) 病理学有关.
- 在AD中WMH的确切临床意义和预测价值仍然不完全理解.
- 了解相对于心室表面的WMH分布可能会为AD的认知功能提供见解.
研究的目的:
- 为了确定WMH是否预测AD的发病.
- 为了研究WMH位置 (距离心室表面的距离) 和AD患者的认知表现之间的关系.
- 为了分析WMH体积和AD认知缺陷之间的关联.
主要方法:
- 招募了171名AD患者和112名认知正常 (NC) 个人的队列.
- 参与者接受了全面的临床评估,包括脑部MRI,神经心理测试 (CEARD-K电池) 和遗传分析.
- 使用自动化方法 (SPM,MATLAB) 量化WMH体积,并根据接近心室表面对WMH进行分类. 对偏斜的WMH体积数据应用了对数转换.
主要成果:
- 与NC组 (6.8±8.1毫升;p < 0.001) 相比,AD组的WMH平均体积 (20.7±18.2毫升) 显着更高.
- 后勤回归显示,总WMH体积,周周结膜WMH (PVWMH) 和深层WMH (DWMH) 与AD风险相关.
- 在阿尔茨海默病患者中,总WMH和腹WMH (JVWMH) 卷与执行功能和记忆测试的表现较差相关,而PVWMH与执行功能和即时回忆缺陷有关.
结论:
- 总的WMH,JVWMH和PVWMH独立地与AD的执行功能,即时记忆和工作记忆缺陷有关,不管海马缩.
- 肌肉内膜干细胞有助于AD风险和认知功能障碍,其影响因其相对于心室表面的位置而有所不同.
- 在阿尔茨海默病的背景下,WMH的空间分布提供了对认知障碍的差异性见解.
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