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Updated: Jan 7, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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新兴的小分子AKR1C3抑制剂开发用于癌症治疗:2021年至2025年的进展

Hao-Nan Gao1, Xing-Sen Wu1, Zhi-Jun Pan1

  • 1Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, School of Pharmacy, Wannan Medical College, Wuhu, 241000, PR China.

European journal of medicinal chemistry
|December 25, 2025
PubMed
概括

化减少酶1C3 (AKR1C3) 通过改变激素活性来驱动癌症生长. 抑制剂的开发显示出治疗前列腺癌和乳腺癌等癌症的前景.

关键词:
在 AKR1C3C3 中.这是一种抗瘤药物.蛋白质结构 蛋白质结构小分子抑制剂小分子抑制剂

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