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乙醇加剧噪音引起的耳损伤:对听力值和毛细胞损失的影响

Seokhwan Lee¹, Jieun Kang¹, Sung-Won Choi²

¹Department of Otorhinolaryngology-Head and Neck Surgery and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.

Hearing research

|December 25, 2025

概括

急性饮酒会使噪音引起的听力损失 (NIHL) 恶化. 与噪音单独相比,同时暴露于乙醇导致大鼠的听觉脑干响应 (ABR) 值变化和外部毛细胞 (OHC) 损失更严重.

科学领域:

耳部毒理学耳部毒理学
听觉神经科学听觉神经科学
环境健康环境健康

背景情况:

噪音引起的听力损失 (NIHL) 是一种普遍存在的听力障碍.
据怀疑,急性饮酒会使NIHL的严重程度恶化.

研究的目的:

调查是否同时暴露于乙醇会加剧NIHL.
评估大鼠模型对听觉脑干响应 (ABR) 值和外部毛细胞 (OHC) 损失的影响.

主要方法:

鼠被分为控制,只有噪音,只有乙醇和噪音与乙醇 (N + E) 组.
乙醇在暴露于噪音之前 (116dB SPL 2小时) 给药.
在84天内测量了ABR值;在12周内组织学评估了OHC损失.

主要成果:

N + E 组显示出明显更大的初始ABR值转移,而不是仅噪声组.
在12周后,N + E组的高频ABR恢复不完全.
在所有暴露组中观察到OHC损失,N + E组的损失最严重.

结论:

同时暴露于乙醇显著加剧NIHL,导致更严重和持久的听力值升高.
乙醇摄入增加了对声学创伤的脆弱性,特别是在娱乐场所.
调查结果强调了饮酒对保护听力健康的公共健康影响.

关键词:

尾虫是什么意思尾虫是什么意思乙醇乙醇是一种头发细胞头发细胞头发细胞听力损失听力损失噪声噪声噪声

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