Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Phenotyping antidepressant treatment response with deep learning in electronic health records.

Translational psychiatry·2026
Same author

MIND GamePack: A novel digital health technology for assessment of participants with and without cognitive impairment.

The journal of prevention of Alzheimer's disease·2026
Same author

Reply to comment on "Prevalence, risk factors, and management of adult asthma in Taipei, Taiwan: A global asthma network study".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Changes in conversational pattern as a clinical trial outcome: a proof-of-concept study using the I-CONECT data.

Innovation in aging·2026
Same author

Can the All of Us sample be reweighted to mirror a nationally representative sample? A comparison of mortality predictors.

Epidemiology (Cambridge, Mass.)·2026
Same author

Improvements in Cogstate Test Performance Depend on Number and Frequency of Prior Tests: Evidence from a Randomized Follow-Up Design.

Alzheimer disease and associated disorders·2026

相关实验视频

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

临床表现 临床表现

Jennifer R Gatchel1,2,3, Kexin Yu4, Phebe Palmer5,6

  • 1Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

像p-tau217,NfL和GFAP这样的等离子体生物标志物在早期阿尔茨海默病和相关痴呆症 (ADRD) 中与神经精神症状 (NPS) 有明显的关联. -tau217在轻度认知障碍 (MCI) 阶段发挥着关键作用.

更多相关视频

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

相关实验视频

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

科学领域:

  • 神经科学是一个神经科学.
  • 生物标志物研究 生物标志物研究
  • 老年学是一门学科.

背景情况:

  • 神经精神症状 (NPS) 在早期阿尔茨海默氏症和相关痴呆症 (ADRD) 中很普遍,影响认知和功能衰退.
  • 对于ADRD中NPS的潜在神经生物学和预后标志物仍然不太了解.
  • 这项研究调查了基线血生物标志物与老年人NPS纵向进展之间的联系.

研究的目的:

  • 检查血生物标志物 (p-tau217,NfL,GFAP) 和纵向NPS轨迹之间的关联.
  • 为了区分情感与整体NPS的生物标志物签名.
  • 了解血生物标志物在预测ADRD过程中NPS的预后价值.

主要方法:

  • 来自认知正常 (CN) 和轻度认知障碍 (MCI) 参与者的血样本的分析.
  • 对基线血生物标志物的测定:-tau217 (p-tau217),神经丝光 (NfL) 和状纤维酸性蛋白 (GFAP).
  • 长度评估NPS使用老年抑郁量表 (GDS-15) 和神经精神病查询问卷 (NPI-Q) 超过7-8年.
  • 线性混合效应模型分析生物标志物与NPS的关联随着时间的推移而发生的变化,控制年龄和性别.

主要成果:

  • 在认知正常的个体中,NfL和GFAP预测了抑郁症状的变化 (GDS-15).
  • 在轻度认知障碍中,p-tau217和NfL与抑郁症状有关,而所有三种生物标志物 (p-tau217,NfL,GFAP) 都预测了整体NPS (NPI-Q) 的增加.
  • -tau217成为MCI组整体NPS最重要的预测因子.

结论:

  • 血生物标志物与NPS的关联在早期ADRD频谱中有所不同.
  • -tau217在预测轻度认知障碍阶段的NPS中发挥着核心作用.
  • 生物标志物签名可以区分情感与更广泛的神经精神病症状,提供预后见解.