肺癌诊断前后抑郁模式的变化:全国性基于人口的研究
Morten Borg1,2, Ingeborg Farver-Vestergaard1,2, Ole Hilberg1,2
1Department of Medicine, Lillebaelt Hospital Vejle, University Hospital of Southern Denmark, Vejle, Denmark.
Psycho-oncology
|December 25, 2025
概括
抗抑郁药的使用在肺癌患者中很常见,在诊断后显著增加. 这凸显了对这些患者综合心理健康支持的需要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 抑郁症是肺癌患者经常出现的并发症.
- 这一群人中抑郁症和抗抑郁药使用的大规模基于人口的证据是有限的.
研究的目的:
- 研究肺癌患者抗抑郁药的使用和医院诊断的抑郁症.
- 通过使用全国范围的队列来比较肺癌诊断前后的这些率.
主要方法:
- 丹麦 (1998-2022) 全国基于登记册的研究.
- 包括所有肺癌患者和匹配的比较队列 (1:4比率).
- 利用国家注册局关于医院诊断和赎回抗抑郁药处方的数据.
主要成果:
- 肺癌患者在诊断前使用抗抑郁药的比例较高 (12.7%对比9.9%),诊断后使用抗抑郁药的比例显著增加 (23.7%对比11.9%在2年).
- 与对照组相比,在肺癌患者中,新抗抑郁药的发病率明显高 (1年后8.4%,2年后13.7%) 和对照组 (1.9%,3.4%).
- 医院诊断的抑郁症在肺癌患者中更为普遍 (2.1%对0.8%),特别是在女性中.
结论:
- 抗抑郁药的使用在肺癌诊断之前普遍存在,并在肺癌诊断后升级.
- 抗抑郁药使用的差异在没有病史的患者中最为明显.
- 系统的心理社会评估和综合心理健康支持对肺癌患者至关重要.
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