临床表现 临床表现
Abhishek Mensegere Lingegodwa1, Albert Stezin1, Jonas S Sundarakumar1
1Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
高心血管风险因素,衰老和痴呆发病率 (CAIDE) 评分预测印度老年人患轻度认知障碍 (MCI) 的风险增加. 早期识别高风险个体对于及时干预以防止认知衰退至关重要.
科学领域:
- 老年学是指老年学的学科.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 心血管风险因素,衰老和痴呆发病率 (CAIDE) 风险评分是用于痴呆风险预测的验证工具.
- 中年心血管风险因素与晚年认知能力下降有关.
研究的目的:
- 调查高风险CAIDE评分组成员与轻度认知障碍 (MCI) 的发展之间的关联.
- 评估CAIDE评分对印度老年人中MCI发展的预测值.
主要方法:
- 来自TATA长度老龄化研究的数据分析.
- 将参与者分为高风险 (>9) 和低风险 (≤9) 的CAIDE评分组.
- 二元逻辑回归以确定一年后发展MCI (CDR=0.5) 的几率,将CAIDE得分作为分类和连续变量.
主要成果:
- 在939名参与者中,48名 (3.5%) 在一年内发展出MCI.
- 高风险的CAIDE组会员显著增加了MCI的几率 (OR=2.58,p=0.004).
- 在CAIDE得分上每增加一分,MCI的几率就会增加33% (Exp β=1.33,p<0.001).
- 没有患上MCI的高危人群在ACE总得分上表现更差.
结论:
- 具有高CAIDE分数的个人面临患MCI的风险较高.
- 研究结果表明,心血管疾病和认知健康之间有共同的病理生理联系.
- 强调需要对心血管疾病和认知能力下降风险的个体进行早期检测和干预.
相关概念视频
01:24Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
01:30Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
01:25Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
01:26Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437