生物标志物 生物标志物
Monica Rosselli1,2, Warren W Barker2,3, Merike Lang1
1Florida Atlantic University, Davie, FL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
白质高强度 (WMHs) 与神经退行有关,年龄和大脑缩是关键预测因素,而不是心血管风险因素. 这项研究发现,西班牙裔和非西班牙裔白人之间没有WMH或其预测因素的种族差异.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 痴呆症研究 痴呆症研究
背景情况:
- 白质高强度 (WMHs) 与阿尔茨海默病 (AD) 和血管痴呆症有关.
- 有限的研究存在于与心血管 (CV) 风险因素或AD病理学相关的WMH体积的种族差异.
- 在美国研究中,西班牙裔的代表性不足,研究了跨种族群体的WMH严重程度.
研究的目的:
- 分析人口,文化,心血管风险因素和AD生物标志物来预测WMH严重程度.
- 为了比较西班牙裔和非西班牙裔白人 (非HW) 人口之间的WMH严重程度及其预测因素.
主要方法:
- 利用来自1佛罗里达ADRC研究的数据,包括252名西班牙裔和172名非HW参与者跨越认知状态.
- 采用线性回归模型,视觉WMH体积作为依赖变量.
- 包括种族,年龄,性别,教育,心血管因子,大脑缩,粉样蛋白PET状态和血p-tau217作为独立变量;语言能力和同文化是西班牙裔群体特有的.
主要成果:
- 在族群之间没有发现心血管风险因素的显著差异.
- 在总体样本中,年龄较大,阳性粉样蛋白PET状态,高的p-tau217,以及较大的海马和皮质缩预测了更高的WMH得分.
- 年龄,海马缩和扩散皮质缩在总样本的多重回归模型中是显著的预测因素;种族不是一个显著的预测因素.
结论:
- 主要预测WMH的严重程度是年龄和神经退行症 (大脑缩) 的测量,而不是心血管风险因素.
- 在西班牙裔和非西班牙裔白人之间没有观察到WMH或CV风险因素的显著差异.
- 研究结果表明,WMH与不同种族的神经退行有关.
相关概念视频
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516