痴呆症护理研究和心理社会因素
Spondita Goswami1, Sarah Hartz2, Amy Oliver1
1Washington University in St Louis, St Louis, MO, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
黑人参与者和患有阿尔茨海默病 (AD) 的家族史的人更有可能拒绝学习他们的AD生物标志物结果. 原因包括潜在的负担和疾病的感知.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 第一个研究量化和定性地评估关于接受阿尔茨海默病 (AD) 生物标志物研究结果的决定.
- 专注于65岁以上的个体,在纵向老龄化队列中具有无损认知能力.
研究的目的:
- 为了确定谁拒绝学习单个AD生物标志物研究结果.
- 确定影响决定接受或拒绝阿尔茨海默病生物标志物的因素.
主要方法:
- 274名参与者提供了他们的生物标记结果 (APOE基因型,成像或血氨基酸).
- 根据人口统计学 (种族,家长史,年龄,性别) 和生物标志物类型分析的结果.
- 定性访谈探讨了参与者的一个子集下降的原因.
主要成果:
- 40%的参与者拒绝了他们的结果.
- 黑人参与者 (调整RR=1.92) 和那些父母有AD痴呆史的人 (调整RR=2.3) 更有可能下降.
- 下降的原因包括感知负担,负面的疾病感知,当前的幸福感,家庭的担忧,以及结果的不确定性.
结论:
- 父母患有AD痴呆症的病史和黑人是结果下降的重要预测因素.
- 家庭阿尔茨海默病史可能会塑造消极的看法,影响学习结果的决定.
- 需要进一步的研究来了解种族差异,并确保选择与个人偏好保持一致.
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