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临床表现 临床表现

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手术后痴呆症在部骨折修复后的老年人中显著影响认知能力下降,特别影响那些没有先前认知障碍的人. 这凸显了预防妄想的重要性,以保持脆弱的老年患者的认知功能.

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科学领域:

  • 老年医学 老年医学
  • 神经科学是一个神经科学.
  • 认知健康 认知健康

背景情况:

  • 妄想症是老年人的急性认知障碍,与包括未来认知衰退在内的不良结果有关.
  • 部骨折修复 (HFR) 患者有患术后妄想症的风险.
  • 在HFR患者中痴呆症的长期认知影响需要进一步调查.

研究的目的:

  • 确定手术后痴呆症在接受关节骨折修复 (HFR) 的患者的1年认知影响.
  • 为了测试妄想在没有基线认知障碍的人群中比那些有先前存在的认知障碍的人群有更大的认知影响的假设.

主要方法:

  • 从STRIDE试验中对200名HFR患者 (年龄≥65,MMSE≥15) 的认知评估进行分析.
  • 一个共识小组对妄想状态和临床痴呆症评分 (CDR) 的判断.
  • 在基线,1个月和1年使用随机截面线性线条模型对迷你心理状态考试 (MMSE) 成绩的纵向评估.

主要成果:

  • 痴呆症发生在36.5%的HFR患者中.
  • 经历狂妄症的患者在1年内MMSE下降率更高,特别是那些没有基线认知障碍的患者 (CDR=0).
  • 在认知不受损的子组中,更大的妄想严重程度与更快的MMSE下降相关.

结论:

  • 手术后妄及其严重程度显著影响HFR后老年人的认知轨迹.
  • 认知正常的个体似乎最容易受到妄的长期认知后果的影响.
  • 预防妄想对于在接受关节骨折手术的老年患者中维持认知功能至关重要.