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临床表现 临床表现

Kelly J Atkins1, Tiffany R Brailow1, Alexandra J Weigand2

  • 1Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.

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概括
此摘要是机器生成的。

针对阿尔茨海默病和相关痴呆症 (ADRD) 的新型家庭诊断途径显示出早期检测的前景. 这种方法结合了数字认知测试和血生物标志物,改善了获得护理和研究机会的机会.

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科学领域:

  • 神经学 神经学
  • 老年学是一门学科.
  • 生物标志物发现发现

背景情况:

  • 诊断阿尔茨海默病和相关痴呆症 (ADRD) 的延迟限制了获得关键干预和参与研究的机会.
  • 为解决这些诊断延迟,开发了一种新的家庭诊断途径,集成数字认知评估和血生物标志物.

研究的目的:

  • 评估ADRD新型家庭诊断途径的可行性,可接受性,可靠性和有效性.
  • 评估家庭数字认知评估 (TabCAT大脑健康评估) 和血生物标志物用于ADRD诊断的实用性.

主要方法:

  • 来自UCSF阿尔茨海默氏病研究中心 (ADRC) 的参与者接受了在家进行数字认知评估和血液采集,并并行进行临床程序.
  • 用英语,西班牙语和中文进行测试,以确保语言多样性.
  • 可行性和可接受性通过瘤学家和参与者反来衡量;可靠性和有效性根据临床数据进行评估.

主要成果:

  • 家庭途径对参与者和瘤学家来说是可行的和可以接受的,80%的参与者更喜欢在家进行评估.
  • 在数字认知子测试 (Match,r=0.85;Birdwatch,r=0.82) 中观察到优异的测试-重试可靠性.
  • 在家进行的数字认知任务在区分认知障碍和无障碍个体 (AUC=0.92) 中表现出高准确度.

结论:

  • 基于家庭的途径是收集数字认知数据和ADRD血生物标志物的有希望的方法,可能有助于早期诊断.
  • 这种方法可以减少测试的障碍,改善对痴呆症护理的准入,并为疾病修饰治疗的资格提供信息.