生物标志物 生物标志物
Rafael Angel Villino-Rodríguez1, Mario Riverol2, Fernando Minguez3
1University Clinica of Navarra, Pamplona, Navarra, Spain.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在轻度认知障碍 (MCI) 中,一种特定的大脑代谢模式,LATE-like (中位时代低代谢) 是常见的. 这种模式表明,与典型的AD模式相比,阿尔茨海默氏症痴呆症的进展较慢.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年学是一门学科.
背景情况:
- 在FDG-PET上,中位时间性低代谢表明边缘主导的与年龄相关的TDP-43脑病变 (LATE).
- 了解LATE在轻度认知障碍 (MCI) 的发生率和特征对于差异诊断至关重要.
- 这项研究调查了MCI患者的LATE类模式,将其与阿尔茨海默病 (AD) 和混合模式进行比较.
研究的目的:
- 用FDG-PET.来确定MCI患者中LATE类模式的发生率.
- 描述临床特征,粉样蛋白负担和MCI患者的认知能力下降与LATE类似的模式.
- 为了比较不同FDG-PET模式的AD痴呆症转化率.
主要方法:
- 207名MCI患者接受了FDG-PET和粉样蛋白PET成像与临床随访.
- FDG-PET扫描被分为LATE类,AD类和混合模式.
- 统计分析比较了临床数据,粉样蛋白负担 (粉样蛋白量表) 和转化率到AD痴呆症.
主要成果:
- 在10.6%的MCI患者中发现了LATE类模式.
- 类似LATE的患者表现出较高的MMSE得分,较低的粉样蛋白阳性和较低的粉样蛋白值.
- 与AD和混合组相比,在LATE类组中转化为AD痴呆的速度明显较慢.
结论:
- 类似LATE的FDG-PET模式是MCI的一个值得注意的发现,在超过10%的病例中存在.
- 这种模式与保持认知功能,减少粉样蛋白负担和疾病轨迹减缓有关.
- 区分LATE类模式对于MCI患者的准确预后和管理至关重要.
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