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Updated: May 12, 2026

Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy
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通过抑制线粒体复合体I和II,CMIT/MIT通过抑制线粒体复合体I和II产生线粒体ROS

Donghyun Kim1, Yusun Shin2, Jong-In Park2

  • 1College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 15588, South Korea; College of Pharmacy, Keimyung University, Daegu, 42601, South Korea.

Free radical biology & medicine
|December 25, 2025
PubMed
概括

5-chloro-2-methyl-4-isothiazolin-3-one和2-methyl-4-isothiazolin-3-one (CMIT/MIT) 生物制剂通过破坏线粒体功能而导致肺损伤. CMIT/MIT抑制了线粒体复合物I和II,导致氧化应激和细胞衰老.

关键词:
在CMIT/MIT中,我们可以电子传输系统的电子传输系统线粒体中的线粒体.有反应性氧物种的反应性氧物种.

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