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非尼尔暴露和心血管毒性:从实验模型的机制性见解和综合风险评估

Zhenzhen Tan¹, Ziwen An², Xiaoqing Xing³

¹Postdoctoral Station of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, 050017, PR China; Department of Toxicology, School of Public Health, Hebei Medical University, East Zhongshan Road, Shijiazhuang 050017, Hebei Province, PR China.

Environmental pollution (Barking, Essex : 1987)

|December 25, 2025

概括

暴露于nonylphenol (NP) 会损害心脏功能,降低收缩性并导致纤维化,特别是在雌性小鼠中. 这种内分泌干扰剂对环境构成中等风险,需要进一步研究和政策考虑.

科学领域:

环境毒理学环境毒理学
心血管研究研究心血管研究
内分泌学在内分泌学.

背景情况:

诺尼尔 (NP) 是一种普遍存在的内分泌干扰化学物质,具有已知的生殖和神经效应.
心血管毒性和NP的综合风险评估仍未得到充分研究.

研究的目的:

在小鼠中研究NP暴露的心血管影响.
阐明NP诱导心脏毒性背后的分子机制.
使用环境化学品有针对性风险评估 (TRAEC) 战略进行NP的系统风险评估.

主要方法:

在昆明小鼠 (75,150,300毫克/公斤28天) 中进行了亚急性口服毒性实验.
通过回声心脏图,组织病理学和心肌细胞收缩性测量评估心脏功能.
转录组分析以确定涉及的分子通路.
环境风险评估的TRAEC框架.

主要成果:

在雌性小鼠中,NP暴露减少了左心室喷射分数和分数缩短.
观察到心肌纤维化,原沉积,心肌细胞收缩/再极化率降低.
转录组分析揭示了242个差异表达的基因,涉及到NP心脏毒性中的放松素信号通路.
通过TRAEC,NP被归类为中等风险化合物 (得分:6.50),高于其他基.

结论:

诺尼尔会损害心脏收缩性,并通过转录组失调诱导纤维化.
放松素信号通路是NP诱导心脏毒性的潜在媒介.
无核电构成重大环境风险,需要监管部门的关注和进一步的人类流行病学验证.

关键词:

心脏有毒性 - 心脏有毒性这是一种非尼尔烯.风险评估风险评估风险评估文字转录学 (Transcriptomics) 是一个学科.

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