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在成长中的老鼠阴茎中,对低剂量二甲基stilbestrol进行微妙的形态和分子反应

Emilie Elmelund1, Marie Berg1, Mikael Pedersen1

  • 1National Food Institute, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark.

Reproductive toxicology (Elmsford, N.Y.)
|December 25, 2025
PubMed
概括

怀孕期间低剂量二甲基stilbestrol (DES) 暴露微妙地改变了雄性大鼠阴茎的发育. DES影响了生殖器结核 (GT) 形态和激素信号,这表明在胎儿男性化过程中直接调制.

关键词:
发展发展发展 发展发展甲基乙乙醇的使用方法内分泌干扰化学物质可以破坏内分泌.雌激素是一种雌激素.生殖器缺陷 生殖器缺陷生殖器结核生殖器的结核.阴茎 阴茎是一个阴茎.

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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...