相关实验视频

Updated: Jan 7, 2026

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Assessing Primary Motor Cortex Excitability and Excitability Modulation by Pairing Transcranial Magnetic Stimulation with Electromyography

Published on: October 7, 2025

优化可塑性:启动cTBS和随后的iTBS之间的时间间隔对电机唤起的电位的影响

Ayan Geng¹, Wenxuan Hu², Junfan Shen¹

¹Department of Rehabilitation Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China; School of Rehabilitation Medicine, Nanjing Medical University, Nanjing 210029, China.

|December 25, 2025

概括

对于运动皮层可塑性,连续的甲爆刺激 (cTBS) 和间歇性的甲爆刺激 (iTBS) 之间的最佳时间间隔为10分钟. 这个间隔最大限度地提高了健康成年人的运动唤起潜力 (MEP).

科学领域:

神经科学是一个神经科学.
神经生理学神经生理学
发动机控制器的控制器

背景情况:

跨磁刺激 (TMS) 协议,包括持续的甲爆刺激 (cTBS) 和间歇性的甲爆刺激 (iTBS),用于调节运动皮层的可塑性.
配对TBS协议的时间可能会影响神经可塑性变化的疗效.

研究的目的:

研究cTBS和iTBS之间的不同时间间隔对运动皮层可塑性的影响.
为了确定最大化促进效应的最佳间隔.

主要方法:

在31名健康成年人中,采用了随机交叉设计.
参与者接受了四个cTBS-iTBS协议,间隔为0,5,10或15分钟.
干预前和后测量了发动机唤起的潜能 (MEP) 幅度.

主要成果:

观察到刺激条件和时间点对正常化的MEP幅度产生显著的主要影响.
cTBS-10分钟-iTBS协议引起了最大的MEP增强,显著超过其他间隔.
欧洲议会议员的幅度呈现出时间依赖的下降,在干预后0分钟达到峰值,并在干预后30分钟最低.

结论:

在cTBS和iTBS之间的时间间隔显著影响运动皮层的可塑性.
10分钟的间隔似乎是最大化促进效应的最佳时间.
这些发现为优化基于TBS的治疗应用提供了初步证据.

关键词:

超塑性超塑性超塑性发动机唤起的潜力塑性是一种可塑性.泰达爆发刺激的刺激

更多相关视频

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

TMS: Using the Theta-Burst Protocol to Explore Mechanism of Plasticity in Individuals with Fragile X Syndrome and Autism

Published on: December 28, 2010

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

相关概念视频

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.