相关实验视频

Updated: Jan 7, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

在治疗慢性阻塞性肺病时,Codonopsis pilosula的机制通过探索网络药理学和多组学来治疗慢性阻塞性肺病

Xiaoai Bao¹, Yizheng Sun¹, Hailong Xu²

¹State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.

Journal of ethnopharmacology

|December 25, 2025

概括

科多诺opsis pilosula (CP) 改善了肺功能,并减少了慢性阻塞性肺病 (COPD) 的老鼠的炎症. 它的机制涉及脂质代谢和TLR4/MAPK/NF-κB通路,支持其传统的使用.

科学领域:

药理学和传统医学的医学.
综合生物学综合生物学
呼吸系统疾病研究呼吸系统疾病研究

背景情况:

(Codonopsis pilosula,简称CP) 是一种具有抗炎功能的中国传统草药.
它在慢性阻塞性肺病 (COPD) 中的治疗作用和机制尚不清楚.

研究的目的:

在COPD的老鼠模型中研究CP的疗效.
通过网络药理学和多组学方法阐明潜在机制.

主要方法:

通过UPLC-QTOF-MS识别的CP化学成分.
在使用香烟烟雾和LPS的老鼠中诱导的COPD.
评估肺功能,肺组织学和炎症标志物.
利用网络药理学,转录学和代谢学来探索机制.

主要成果:

在COPD大鼠中,CP治疗改善了肺功能,并减少了气道/气膜损伤.
网络药理学确定了关键的标 (TNF,IL-1β,NF-κB,MAPK3,TLR4) 和通路 (PI3K-Akt,MAPK,NF-κB). 通过网络药理学确定了关键的标 (TNF,IL-1β,NF-κB,MAPK3,TLR4) 和通路 (PI3K-Akt,MAPK,NF-κB).
多种OMIC揭示了脂质代谢 (甘油脂,酸) 和亡调节的参与.

结论:

科多诺opsis pilosula通过增强肺功能和减少炎症来证明COPD的治疗潜力.
机制包括调节脂质代谢和抑制TLR4/MAPK/NF-κB信号通路.
研究结果提供了证据证明CP的传统使用及其在COPD管理中的潜力.

关键词:

慢性阻塞性肺病是一种慢性阻塞性肺病.科多诺普西斯 (Codonopsis pilosula) 是一个的植物.机理机制机理机制多种组合的多种组合.

更多相关视频

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression

Published on: February 24, 2023

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

相关概念视频

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Chronic Obstructive Pulmonary Disease-V: Management

Chronic Obstructive Pulmonary Disease-V: Management

Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

COPD: Management Using Bronchodilators and Corticosteroids

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...