来自Vatica mangachapoi的达马尔树脂的抗炎三烯酸
Rui-Jie Feng1, De-Li Chen2, Jian-He Wei1
1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou 570311, China.
来自Vatica mangachapoi的Dammar树脂产生了32种三类化合物,包括新型化合物. 几种三类药物通过降低瘤亡因子-α (TNF-α) 和介素-6 (IL-6) 水平,显示出抗炎性质.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 达马尔树脂来自Vatica mangachapoi,是一种复杂的天然化合物的混合物.
- 三类是有机化合物的多样类别,具有各种生物活动.
研究的目的:
- 从Vatica mangachapoi dammar树脂中分离和表征三类化合物.
- 评估分离的三烯酸的抗炎作用潜力.
主要方法:
- 使用甲醇提取分离化合物.
- 使用高分辨率电喷射电离质谱法 (HRESIMS),核磁共振 (NMR),紫外线 (UV) 和电子循环二元化 (ECD) 光谱法来阐明结构.
- 通过测量RAW264.7细胞中脂聚糖 (LPS) 诱导的瘤亡因子-α (TNF-α) 和介质素-6 (IL-6) 的水平来评估抗炎活性.
主要成果:
- 隔离了32种三类化合物,包括5种以前未被描述的化合物和4种合成但未自然分离的化合物.
- 化合物2,6,22和29显著降低了LPS诱导的TNF-α水平.
- 化合物3,13,16和17在10μM度下显著降低了IL-6水平.
结论:
- 这项研究成功地从Vatica mangachapoi dammar树脂中确定了新的和已知的三类化合物.
- 几种孤立的三类化合物具有显著的抗炎活性潜力,需要进一步研究.
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