胰腺炎在患有胰腺固体伪囊瘤的儿科患者中:一个单一的中心经验
Stephen J Hartman1, Nicolas Noriega2, Raphael M Parrado3
1Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH; Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Journal of pediatric surgery
|December 25, 2025
概括
固体伪毛囊瘤 (SPN) 是一种罕见的儿科胰腺瘤. 在SPN切除之前的遗传和解剖评估可能会改善对儿童手术后胰腺炎风险的理解.
科学领域:
- 儿科瘤学 儿科瘤学
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 固体伪毛囊瘤 (SPN) 是一种罕见的,低度的恶性儿科胰腺瘤,预后良好.
- 这项研究侧重于接受SPN切除的儿科患者的特征,遗传学和结果.
研究的目的:
- 描述患有SPN的儿科患者的临床特征,遗传因素和术后结果.
- 调查SPN切除和胰腺炎的发展之间的关联.
主要方法:
- 在2010年至2023年期间在单一中心接受SPN切除的儿科患者的回顾性审查.
- 收集的数据包括SPN位置,手术程序以及急性复发性胰腺炎 (ARP) 和慢性胰腺炎 (CP) 的发生率.
- 患有ARP/CP的患者接受了与胰腺炎相关基因的基因测试.
主要成果:
- 包括10名女性患者,平均年龄为15.0岁.
- 五名患者接受了胰腺双管切除术,5名患者接受了部分胰腺切除术.
- 三名患者患有术后ARP/CP,所有患者的胰腺头部都有SPN. 这些患者有遗传变异 (CFTR) 或解剖问题 (胰腺分裂).
结论:
- 儿科SPN患者需要多学科的护理.
- 切除前的遗传和解剖评估可以预测儿科SPN患者的术后胰腺炎风险.
- 需要进一步的研究,以了解SPN切除儿童后的结果.
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