心理测量开发和内部验证一个简短版本的克罗恩门囊生命质量量尺度的内部验证
Lieven G M Mulders1, Kim J Beek2, Jeroen A W Tielbeek3
1Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, The Netherlands.
概括
克罗恩门囊-生活质量 (CAFQOL) 尺度有效地测量了患有围塞克罗恩病的患者的生活质量. 一个新的简短版本为监测疾病进展提供了一个可行的工具.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 生活质量研究 研究 生命质量研究
背景情况:
- 周围抽性克罗恩病 (PFCD) 显著影响患者的健康相关生活质量 (HRQoL).
- 需要验证的工具来评估HRQoL和监测PFCD患者的治疗反应.
研究的目的:
- 在一个独立的患者队列中验证克罗恩门囊-生活质量 (CAFQOL) 尺度.
- 开发和内部测试CAFQOL规模的简体版本,以有效监测PFCD中的疾病.
主要方法:
- 一项前性多中心研究,涉及接受医学和/或手术治疗的PFCD患者.
- 评估患者报告的结果,包括CAFQOL和IBDQ-32,以及多个时间点的临床和MRI测量 (FDA,PDAI,MAGNIFI-CD).
- 使用经典测试理论和项目响应理论来推导和测试简短的CAFQOL版本的心理测试评估.
主要成果:
- 在52周的CAFQOL尺度表现出显著的改善 (SRM -1.26) 并与IBDQ-32 (r = -0.77) 显示出强烈的收有效性.
- 与临床和MRI措施的弱相关性支持了差异性有效性.
- 开发了一个9项简短的CAFQOL版本,显示出高可靠性和与全尺度有很强的相关性,平均完成时间为1分钟.
结论:
- 该CAFQOL尺度是一个可靠和响应的工具,用于捕捉PFCD患者HRQoL的有意义变化.
- 简短的CAFQOL版本是临床实践中常规疾病监测的实用和可行的工具.
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