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在质母细胞瘤瘤微环境中的星球细胞

Shu Cui¹, Fan Guan¹, Xuetong Li¹

¹The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Central South University, Changsha 410013, Hunan, China; The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, Hunan, China; FuRong Laboratory, Changsha 410078, Hunan, China.

Biochimica et biophysica acta. Reviews on cancer

|December 25, 2025

概括

质母细胞瘤 (GBM) 天体细胞重新编程以支持瘤生长和抵抗. 针对这些重编程的星细胞提供了一个有希望的策略,以改善侵略性脑瘤的结果.

科学领域:

神经瘤学神经瘤学
癌症生物学癌症生物学
瘤微环境研究研究

背景情况:

质母细胞瘤 (GBM) 是一种致命的成年大脑瘤,由于异质性和治疗耐药性,预后不佳.
GBM瘤微环境 (TME) 是一个复杂的生态系统,驱动瘤进展和免疫逃避.
恒星细胞,传统上是支持细胞,现在被认为是GBM病变的关键参与者.

研究的目的:

审查星体细胞在GBM微环境中的多方面的作用.
探索星球细胞表型多样性和GBM中的调控机制.
讨论针对GBM中的星细胞的治疗潜力.

主要方法:

文献综述侧重于天体细胞对GBM的贡献.
对天体细胞重编程,可塑性和异质性的分析.
对天体细胞-TME相互作用和细胞间通信的检查.

主要成果:

星球细胞经历表型重编程,通过代谢辅助,免疫抑制,入侵和治疗耐药性来支持GBM.
天体细胞表现出由GBM因素影响的亚型 (代谢,炎症,质细胞,衰老相关) .
天体细胞通过免疫抑制,代谢交叉和通过TNT和EV进行通信来塑造TME.

结论:

星球细胞是GBM TME的关键编排者,促进瘤的进展和抵抗.
针对天体细胞重编程及其前瘤功能,为GBM提供了一个新的治疗途径.
对天体细胞生物学和向策略的进一步研究对于改善GBM患者的治疗结果至关重要.

关键词:

质母细胞瘤 (glioblastoma) 是一个免疫调节免疫调节瘤相关的星形细胞.瘤微环境是一个微环境.

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