生物标志物 生物标志物
1Wenzhou Medical University, First Affiliated Hospital, Wenzhou, Zhejiang, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
在早期阿尔茨海默氏症 (AD) 中使用莱卡内马布治疗显示,视网膜神经纤维层厚度显著增加. 需要进一步的研究来证实lecanemab对AD患者眼睛的疗效和安全性.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 粉样β (Aβ) 聚合物的积累与阿尔茨海默氏症 (AD) 病原发生有关.
- 针对Aβ原纤维素的单克隆抗体Lecanemab正在研究早期的AD.
- 这项研究探讨了lecanemab对早期AD患者视网膜结构的影响.
研究的目的:
- 评估lecanemab对早期阿尔茨海默病患者视网膜结构厚度的影响.
- 评估黄斑视网膜神经纤维层 (RNFL) 和视网膜细胞复合体 (RGC) 厚度的变化.
主要方法:
- 进行了一个为期一个月的单中心3期试验.
- 早期AD和粉样蛋白证据的参与者 (50-90岁) 接受了静脉注射lecanemab (10毫克/公斤两周一次).
- 光学连贯性断层扫描 (OCT) 从基线到一个月测量了RNFL和RGC厚度.
主要成果:
- 8名参与者接受了lecanemab的治疗.
- 平均RNFL厚度从38.16微米增加到41.28微米 (差异:3.11微米,p=0.004).
- 平均RGC厚度显示,从70.30μm到70.61μm的变化不显著 (差异:0.31μm,p=0.819).
结论:
- 莱卡尼马布治疗导致RNFL显著加厚,表明对轴突结构的潜在影响.
- 该研究表明,lecanemab可能会降低粉样蛋白标记物,并在AD早期影响视网膜神经元结构.
- 需要进行长期试验,以确定lecanemab在早期阿兹海默症患者眼中的有效性和安全性.
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