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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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生物标志物 生物标志物

Ting Qiu1,2,3,4, Zhen-Qi Liu5,6, Jonathan Gallego Rudolf5,7,8

  • 1Integrated Program in Neurosciences, McGill University, Montréal, QC, Canada.

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在PubMed 上查看摘要

概括
此摘要是机器生成的。

阿尔茨海默病 (AD) 的脑部变化,包括皮质厚度和扩散性,在症状出现前几年就开始. 这些结构变化遵循非线性模式,以应对粉样β (Aβ) 病理.

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科学领域:

  • 神经成像是一种神经成像.
  • 阿尔茨海默氏症疾病研究研究
  • 大脑结构分析 分析大脑结构

背景情况:

  • 阿尔茨海默病 (AD) 涉及粉样β (Aβ) 和病理,通常与灰质损失有关.
  • 临床前的AD可能会显示皮质厚度 (CT) 增加,与后期的减少形成鲜明对比.
  • 纵向数据对于了解AD进展中的早期结构变化至关重要.

研究的目的:

  • 为了研究Aβ和tau病理和大脑结构 (CT,平均扩散率,海马体积) 在10年内之间的关联.
  • 为了确定与Aβ阳性相对的结构性大脑变化的纵向轨迹.
  • 探索阿尔茨海默病的临床前和临床前阶段的变化.

主要方法:

  • 部分最小方形分析 (PLS) 用于识别Aβ阴性和Aβ阳性组中的病理结构关联.
  • 评估了AD病理和结构性措施之间的截面和纵向关联.
  • 从Aβ阳性开始的时间被估计跟踪随时间的结构变化.

主要成果:

  • 较高的Aβ沉积与Aβ阴性个体的MDT降低和CT增加相关.
  • 具有Aβ阳性的个体表现出相反的关联 (增加MDT,减少CT).
  • MDT遵循U形模式,CT则遵循Aβ病理的反向U形模式,出现在Aβ阳性之前的几年.

结论:

  • 作为对Aβ病理的反应,大脑的结构变化在临床症状出现前几十年就开始了.
  • 这些变化呈现出高度非线性轨迹,可能涉及神经炎症或大脑胀.
  • 了解这些早期的非线性变化是临床前AD干预的关键.