生物标志物 生物标志物
Jiongqi Qu1, Sophie A Martin1, Anna Schroder1
1University College London, London, United Kingdom.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
自动化海马细分工具显示不同临床准备. 在疾病敏感性方面,FastSurfer和SynthSeg表现出色,而FastSurfer,SynthSeg,GIF和nnUNet提供了比FreeSurfer更好的测试-重新测试可靠性.
科学领域:
- 神经成像是一种神经成像.
- 人工智能的人工智能
- 医学诊断 医学诊断 医学诊断
背景情况:
- 深度学习被广泛用于痴呆症研究中的海马体自动细分.
- 目前的重点往往是细分精度,忽视了临床准备因素,如疾病敏感性和可靠性.
- 评估这些因素对于将自动化工具转化为临床实践至关重要.
研究的目的:
- 评估对阿尔茨海默病和轻度认知障碍的敏感性,以及五个自动化海马细分管道的测试-重新测试可靠性.
- 为了将这些管道与FreeSurfer进行比较,这是一个广泛使用的标准.
- 建立一个工作流程来评估自动化细分工具的临床准备.
主要方法:
- 我们比较了五个深度学习管道 (FastSurfer,SynthSeg,GIF,InnerEye,nnUNet) 与FreeSurfer 7.4.4 的情况.
- 通过使用ADNI (n=2299) 和NACC (n=1852) 的T1加权MRI扫描来评估组级敏感性.
- 使用扫描器内部,扫描器间和运动文物数据集 (1264次扫描) 评估可靠性.
主要成果:
- 所有管道都显示出对阿尔茨海默病敏感性的影响大小;FastSurfer和SynthSeg显示出最高的效果.
- 对敏感度的管道排名在不同的认知状态和扫描质量中保持一致.
- 在内部扫描器数据上,FastSurfer,SynthSeg,GIF和nnUNet的测试可靠性明显高于FreeSurfer.
结论:
- 该研究提供了一种工作流程,用于评估自动化海马体细分工具的临床准备性.
- 由于其高灵敏度和可靠性,FastSurfer和SynthSeg具有很强的临床应用潜力.
- 评估策略可以为开发可靠的管道提供信息,可以抵御文物和扫描变化.
相关概念视频
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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