生物标志物 生物标志物
Stefan de Vries1, Katalin Farkas1, Mara Ten Kate1
1Department of Radiology & Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, Amsterdam, Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
大脑年龄差距 (BAG) 预测主观认知衰退 (SCD) 和轻度认知障碍 (MCI) 患者的痴呆症进展. 在早期疾病阶段,BAG比视觉评分表 (VRS) 提供了附加值.
科学领域:
- 神经成像是一种神经成像.
- 人工智能在医学中的应用
- 痴呆症研究 痴呆症研究
背景情况:
- 早期发现痴呆症对于干预至关重要.
- 视觉评分尺度 (VRS) 在MRI上评估大脑缩以预测痴呆症.
- 在疾病的早期阶段存在VRS限制,例如轻度认知障碍 (MCI).
- 大脑年龄差距 (BAG),来自AI分析的MRI,显示了检测痴呆症相关的大脑变化的潜力.
研究的目的:
- 评估大脑年龄差距 (BAG) 是否可以预测主观认知衰退 (SCD) 和MCI患者的痴呆症进展.
- 为了比较BAG的预测值与传统的视觉评分尺度 (VRS).
主要方法:
- 利用了来自757名参与者 (391名SCD,366名MCI) 的MRI数据,随访时间超过2年.
- 在T1加权MRI扫描上使用BrainageR软件计算BAG.
- 采用考克斯回归来模型痴呆症进展风险,包括BAG,年龄,性别和MMSE.
- 通过结合VRS (中叶,全身,部缩) 来评估BAG的附加预测价值.
主要成果:
- 224名参与者发展为痴呆症 (38名SCD,186名MCI).
- BAG显著预测了痴呆症的进展,显示了超越VRS的附加值.
- BAG的预测能力在SCD组中最强,其中VRS没有提供额外的好处.
- 在MCI集团中,BAG的预测价值下降,当VRS被包括在内时变得微不足道.
结论:
- 大脑年龄差距 (BAG) 是SCD和MCI中痴呆症进展的重要预测因素.
- BAG比VRS提供了额外的预测价值,特别是在认知衰退 (SCD) 的早期阶段.
- BAG显示出作为痴呆风险评估的敏感生物标志物的潜力,特别是当传统VRS效率较低时.
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