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临床表现临床表现

Zarui A Melikyan¹, Zeinah Al-Darsani², Michael A Yassa²

¹University of California Irvine, Irvine, CA, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|December 25, 2025

概括

长时间的睡眠与非常老年人的大脑体积减少有关. 在粉样蛋白阴性个体中,长时间睡眠与较低的白质体积相关,而在粉样蛋白阳性个体中,它与较低的灰质体积有关.

科学领域:

神经成像是一种神经成像.
睡眠医学睡眠医学
老年学是一门学科.

背景情况:

之前的研究表明,在老年人中,睡眠时间延长和大脑体积减少之间存在联系.
粉样蛋白病理对认知正常个体这种关联的影响仍然不清楚.

研究的目的:

调查90岁及以上认知正常人自我报告的睡眠时间与脑磁共振成像体积测量之间的关系.
为了确定粉样蛋白状况是否会改变睡眠时间和大脑结构之间的关联.

主要方法:

利用了90+研究的数据,包括脑部MRI和粉样蛋白PET扫描的认知正常参与者.
睡眠时间是自我报告和分类 (<8,8=参考,>8小时).
通过多重线性回归分析了 supratentorial灰质,白质,海马和白质超强度体积,按粉样蛋白状况分层.

主要成果:

这项研究包括104名参与者 (平均年龄为93岁),其中36%是粉样蛋白阳性.
在粉样蛋白阴性参与者中,睡眠时间超过8小时的人与参考组相比,白质体积显著降低 (p=0.03).
在氨基酸阳性参与者中,睡眠时间超过8小时的人与参考组相比,灰质体积显著降低 (p=0.02).

结论:

长时间的睡眠时间与粉素阴性,认知正常的老年人白质体积减少有关.
在粉样蛋白阳性,认知正常的老年人中,长时间的睡眠时间与灰质体积的减少有关.
这些发现表明,长时间睡眠和老化中的大脑结构之间的关系可能受到潜在的粉样蛋白病理学的影响.

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