生物标志物 生物标志物
John Nguyen1, Tara Riddle2,3, Daniel A Llano4
1Clinical Imaging Research, Carle Foundation Hospital, Urbana, IL, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
主观认知衰退 (SCD) 显示了大脑活动模式的改变. 在SCD大脑中的区域同质性 (ReHo) 可以高准确地预测未来的阿尔茨海默病评估等级分数.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 大脑的连接性 大脑的连接性
背景情况:
- 主观认知衰退 (SCD) 代表了早期阿尔茨海默病 (AD) 症状而没有客观认知障碍.
- 在SCD中表征微妙的大脑变化对于预测AD进展至关重要.
研究的目的:
- 调查SCD和健康对照 (HC) 个体之间静止状态大脑活动的差异.
- 使用神经影像特征开发未来SCD认知衰退的预测模型.
主要方法:
- 分析了来自70名SCD和100名HC参与者的纵向MRI和ADAS-Cog数据.
- 休息状态fMRI数据被处理为计算3D区域均性 (ReHo).
- 一个普通的最小平方回归模型使用基线ReHo和临床数据预测了未来的ADAS-Cog得分.
主要成果:
- 与HC相比,SCD个体表现出额头/背ReHo降低和时间ReHo增加.
- ReHo与特定大脑区域的认知衰退相关,包括胰岛,叶和顶叶.
- 预测模型在4年的ADAS-Cog得分中实现了0.72的r2,单独超过了基线临床得分 (r2=0.64).
结论:
- 静止状态ReHo揭示了SCD中独特的神经同步模式.
- 这些ReHo特征有可能改善早期AD轨迹的长期预测.
- 像ReHo这样的神经成像标记可以提高主观认知衰退的个体的监测和管理.
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