[关闭循环调节系统用于下肢关节运动,基于脊柱中央模式发生器的电刺激]
Xiaoyan Shen1,2, Xinlong Zhang1, Xiongjie Lou1
1School of Information Science and Technology, Nantong University, Nantong, Jiangsu 226019, P. R. China.
概括
脊髓内微刺激 (ISMS) 在脊髓损伤 (SCI) 的老鼠中激活了的后肢运动,使用模糊逻辑控制的PID算法. 这项技术可以实时控制脚关节的运动,提供了一种新的康复方法.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 康复技术 康复技术 康复技术
背景情况:
- 脊髓损伤 (SCI) 经常导致,严重影响四肢功能.
- 脊髓内微刺激 (ISMS) 是一种有前途的康复技术,通过刺激脊髓来恢复四肢的运动.
- 目前的ISMS方法需要精确控制刺激参数,以有效地激活神经回路.
研究的目的:
- 开发和评估用于脊内微刺激 (ISMS) 的模糊逻辑控制自调比例积分导数 (PID) 算法.
- 为了实现实时控制后肢脚关节运动在老鼠脊髓损伤 (SCI).
- 为了研究同时调整刺激参数 (振幅,脉冲宽度,频率) 激活中央模式发生器 (CPG) 的有效性.
主要方法:
- 一个模糊的逻辑控制的自调 PID 算法被实施来管理 ISMS.
- 三个关键的电刺激参数 (振幅,脉冲宽度,频率) 被同时调整.
- 在患有SCI的老鼠身上进行了动物实验,以评估ISMS系统的控制性能.
- 该系统的重点是激活远部运动器的中央模式发生器 (CPG).
主要成果:
- 在麻的老鼠中,ISMS系统成功激活了CPG,并控制了后肢关节的运动.
- 关节角度跟踪的根平均平方误差 (RMSE) 为2.50°.
- 关节角度跟踪的正常化根平均平方误差 (NRMSE) 为5.78%.
结论:
- 开发的模糊逻辑控制ISMS系统有效地实现了SCI大鼠脚关节运动的实时控制.
- 单个电极脊内电刺激可以引导的后肢运动沿着预设的轨迹.
- 这项研究表明了ISMS中先进的控制算法的潜力,用于SCI康复.
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