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Updated: Jan 7, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

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NX-1607:解除Cbl-b制动,通过MAPK/ERK通路促进T细胞激活

Alex To1, Ryohichi Sugimura2,3

  • 1School of Biomedical Sciences, University of Hong Kong, Hong Kong, Hong Kong.

Journal for immunotherapy of cancer
|December 25, 2025
PubMed
概括

用NX-1607抑制卡西塔斯B淋巴瘤-b (Cbl-b) 通过向PLCγ1-MAPK/ERK通路来增强T细胞激活. 这一发现为开发抗癌新型免疫疗法提供了关键的见解.

关键词:
一个T细胞细胞.

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