生物标志物 生物标志物
Paulo Eduardo Lahoz Fernandez1, Alan Cronemberger Andrade1, Paulo Henrique Ferreira Bertolucci1
1Federal University of São Paulo - UNIFESP, São Paulo, SP, Brazil.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
本案例研究突出了混合性痴呆症中罕见的MRI模式,显示出扩大的周周血管空间 (EPVS) 和缺口性心脏病发作. 这种被称为criblé状态和lacunaire状态的组合与认知能力下降有关.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 神经成像是一种神经成像.
背景情况:
- 扩大周血管空间 (EPVS) 是大脑动脉周围充满液体的空间,通常在基底 (BG-EPVS) 和半圆中心 (CSO-EPVS) 中看到.
- 缺口性心脏病发作是与血管痴呆 (VaD) 和阿尔茨海默病 (AD) 的认知衰退相关的小病变,有助于混合痴呆 (MD).
- 形状态和缺陷状态描述了分别扩大了EPVS和缺陷心脏病的特定MRI模式,特别是在深层大脑结构中.
研究的目的:
- 报告一种罕见的混合痴呆症 (MD) 病例,具有独特的MRI模式.
- 描述认知障碍患者的criblé状态和空洞状态的共存.
主要方法:
- 分析了一位患有认知衰退的85岁妇女的临床和成像特征.
- 进行脑部MRI,以评估扩大周血管空间 (EPVS) 和缺口性心脏病发作.
- 进行了神经心理评估,以量化认知缺陷.
主要成果:
- 这位患者在六年内呈现出渐进的amnestic和dysexecutive认知障碍.
- 磁力共振扫描显示了部和海马体缩,慢性白质变化,多重基底-EPVS (BG-EPVS) 和基底中的多焦点性心脏病发作.
- 神经心理测试显示记忆和执行功能受损.
结论:
- 基底-EPVS,特别是当与缺口性心脏病发作相关时,与混合痴呆症的认知衰退密切相关.
- 这一案例强调了认识到MD和其他痴呆症患者中criblé状态和lacunaire状态的同时出现的重要性.
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