痴呆症护理研究和心理社会因素
Douglas W Scharre1, Jessica Truelove1, Renee Kovesci1
1Ohio State University Wexner Medical Center, Columbus, OH, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
临床指南有助于识别和管理接受早期阿尔茨海默病 (AD) 抗粉胺疗法的患者. 这些指导方针确保对因AD (MCI-AD) 和轻度AD痴呆症 (ADD) 的轻度认知障碍进行适当的患者选择,监测和治疗调整.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 抗粉样蛋白疗法 (AAT) 在阿尔茨海默病 (MCI-AD) 和轻度AD痴呆症 (ADD) 引起的轻度认知障碍方面表现有前途.
- 有效的患者选择和监测对于优化结果和最大限度地降低AAT在现实环境中的风险至关重要.
研究的目的:
- 在俄俄州立大学为处方抗粉样蛋白疗法 (AAT) 提出临床指南.
- 详细说明患者鉴定,评估,治疗和监测MCI-AD和轻度ADD中的AAT的标准.
主要方法:
- 制定了结合患者选择标准的指导方针 (认知衰退,诊断,功能状态).
- 包括排除标准 (抗凝血剂,MRI禁忌,精神病症状).
- 特定的监测协议 (每6个月进行一次认知/功能评估) 和AAT停止标准.
主要成果:
- 准则定义了认知评估 (SAGE,BrainTest,MMSE,MoCA) 和功能状态的操作截止值.
- 如果粉样蛋白清除,建议重新评估粉样蛋白病理,并在18个月后停止使用donanemab.
- 纳入FDA对lecanemab和donanemab的处方信息,包括剂量,定位和MRI安全性.
结论:
- 这些指南为在临床实践中有效的AAT处方和监测提供了一个框架.
- 这些指导方针旨在改善阿尔茨海默病早期治疗的患者结果和安全性.
- 鼓励进一步的数据驱动研究和辩论,以完善AAT指南.
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