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临床表现 临床表现

Olivia Goulette1, Deling He1, Kristin E Basche1

  • 1Department of Communication Sciences and Disorders, University of Wisconsin- Madison, Madison, WI, USA.

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概括
此摘要是机器生成的。

创伤性脑损伤 (TBI) 史结合早期阿尔茨海默病 (AD) 粉样蛋白积累可能加快沟通下降,特别是减少字母流性和增加语音不流性在认知不受损的个体.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 认知科学 认知科学

背景情况:

  • 创伤性脑损伤 (TBI) 和阿尔茨海默病 (AD) 独立地损害认知和语言功能.
  • 创伤病史和AD生物标志物对纵向认知和语言变化的相互作用仍未得到充分研究.

研究的目的:

  • 调查TBI史如何与AD相关预测因素 (粉样蛋白,,APOE ε4) 相互作用,以影响认知和语言轨迹在认知不受损的个体.
  • 在结合TBI和AD风险因素的背景下,识别认知和语言衰退的早期指标.

主要方法:

  • 来自威斯康星州阿尔茨海默氏症预防注册 (WRAP) 的308名认知正常参与者的分析.
  • 评估粉样蛋白和蛋白PET成像,APOE ε4状态,以及自我报告的TBI史.
  • 线性混合效应模型检查了TBI历史*年龄对执行功能,语义语音处理和连接语音措施的相互作用,并对共变量进行调整.

主要成果:

  • 在粉样蛋白阳性 (A+) 参与者中,创伤史与字母流利度 (p=0.036) 和流利度指数 (p=0.035) 的平均下降有关,这表明失流言语的增加.
  • 在tau阳性或APOE ε4载体子组中,TBI病史和纵向结果之间没有发现显著的关联.

结论:

  • 创伤史与早期的粉样蛋白积累相结合,可能会加速认知不受损的个体的沟通下降.
  • 结果表明TBI和AD病理学对语义和语音检索的复合影响.
  • 早期的语言变化,包括流利性降低和语音不流利性增加,可能是未来衰退的潜在指标.