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临床表现 临床表现

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概括
此摘要是机器生成的。

APOE基因型意识影响老年人的认知表现. 对于APOE ε4载体,知道它们的基因型在第一次测试时降低了反向数字跨度 (BDS) 得分,但在最后一次测试时提高了得分.

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科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 心理学 心理学 心理学

背景情况:

  • 随着Apolipoprotein E (APOE) 测试的越来越多,需要了解其对认知功能的影响.
  • APOE基因型和对自己的基因型的认识可能会影响认知表现,特别是在老年人中.

研究的目的:

  • 调查APOE基因型,基因型意识和任务顺序对数字跨度性能的影响.
  • 检查APOE ε4载体状态和这种状态的意识如何与认知测试进行交互.

主要方法:

  • 196名没有认知障碍的老年人 (平均年龄71.14) 参与,其中69.4%是APOE ε4载体.
  • 参与者在被告知研究重点是APOE基因型和认知后,随机顺序完成了前向和后向数字跨度 (FDS,BDS) 测试.
  • 分析包括用于基因型和意识效应的MANOVA,以及用于任务顺序相互作用的探索性ANOVA.

主要成果:

  • 没有APOE基因型或意识对FDS/BDS性能产生显著的初级影响.
  • 在基因型,意识和任务顺序之间发现了BDS表现的显著相互作用 (p=.026).
  • 在APOE ε4载体中,对基因型的认识与当任务是第一个时 (p=.052) 的BDS表现较差,但当任务是最后一个时 (p=.016) 的表现更好.

结论:

  • 对于APOE ε4载体,基因型意识对后置数字跨度性能的影响取决于任务顺序.
  • 意识到APOE ε4状态可能会引起刻板印象的威胁,在早期测试时会对表现产生负面影响.
  • 相反,意识可能会在以后进行测试时提高性能,这表明基因型,意识和测试环境之间的复杂相互作用.