生物标志物 生物标志物
Jiaying Lu1, Jie Wang2, Huiwei Zhang3
1Department of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, Shanghai, China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
阿尔茨海默病 (AD) 生物标志物显著改善了记忆诊所患者的预后预测. 量化tau负担,特别是在新皮层区域,提供优越的预后价值比AD连续的二进制评估.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物研究 生物标志物研究
- 临床诊断 临床诊断 临床诊断
背景情况:
- 阿尔茨海默病 (AD) 的临床生物诊断越来越被认可.
- 生物概况有助于疾病监测和预后,但来自记忆诊所的现实数据有限.
研究的目的:
- 在记忆诊所环境中评估AD核心生物标志物的预后价值.
- 为了比较定量与二元生物标志物评估对预测临床进展的有效性.
主要方法:
- 211名认知问题受试者和31名对照受到了纵向随访 (平均1.89年).
- 阿尔茨海默病理学评估包括粉胺-PET/血p-tau217和tau-PET.
- 生物标志物被评估为二进制状态和定量tau负担 (MTL,NEO);临床进展是主要结果.
主要成果:
- 年龄和性别是临床进展的重要风险因素.
- 将生物标志物单独纳入有显著改善的预后值 (AUC 0.73-0.80),在NEO中量化tau负担表现最好.
- 结合粉样蛋白和蛋白生物标志物进一步改善了预后 (AUC 0.77-0.82),NEO中的二元粉样蛋白+定量蛋白是最佳的.
结论:
- 阿尔茨海默症核心生物标志物显示出改善记忆诊所人口的临床预后的前景.
- 量化tau负担评估优于二进制评估来预测预后,特别是在AD连续体内.
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