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临床表现 临床表现

Sofía A Rodriguez-Araña1,2, Diana Carolina Oviedo1,2,3, Adam E Tratner4

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概括
此摘要是机器生成的。

认知储备 (CR) 可能缓冲老年人与神经炎症相关的认知衰退. 通过教育和职业加强CR可以减轻发展中国家的残疾.

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科学领域:

  • 老年学和神经科学 在
  • 生物标志物和疾病病理学

背景情况:

  • 神经退行与脑血管疾病 (CVD) 相关,影响老年人的日常功能和认知健康.
  • 血液生物标志物可以表明神经炎症和脑血管问题,而认知储备 (CR) 则提供了对认知衰退的保护性缓冲.
  • 在发展中国家,获得构建CR的经验,如教育和复杂职业,是有限的.

研究的目的:

  • 为了研究认知储备 (CR) 和特定的基于血液的生物标记物 (干白素-18,血管细胞粘附分子-1,可溶性细胞间粘附分子-1,胰腺多) 与认知有关的关系.
  • 探索CR在生物标志物和认知功能之间的关联中的潜在调解作用.

主要方法:

  • 来自巴拿马衰老研究倡议-健康差异研究 (PARI-HD) 的两个样本 (N=429) 的横截面分析,包括65岁以上的没有痴呆症的成年人.
  • 全球认知通过迷你精神状态考试 (MMSE) 进行评估;CR使用教育,职业复杂性和日常生活工具活动 (IADL) 的综合得分计算.

主要成果:

  • 观察到显著的性别和队列差异;男性通常年龄较大,职业更复杂,IL18/PPP水平更高.
  • 与第2队列相比,第一队列的参与者年龄较大,受教育程度较低,独立程度较低,IL18,PPP,sVCAM1和sICAM1水平较高.
  • 调解分析证实,CR调解sVCAM1和sICAM1对全球认知的影响,根据年龄,性别和队列进行调整.

结论:

  • 在老年人中,神经炎症生物标志物,CR和认知功能之间存在显著的关联.
  • 旨在加强CR的公共卫生政策可能会减少巴拿马等发展中国家的神经炎症相关的残疾.