临床表现 临床表现
Sofía A Rodriguez-Araña1,2, Diana Carolina Oviedo1,2,3, Adam E Tratner4
1Escuela de Psicología, Universidad Santa María la Antigua (USMA), Panamá, Panamá, Panama.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
认知储备 (CR) 可能缓冲老年人与神经炎症相关的认知衰退. 通过教育和职业加强CR可以减轻发展中国家的残疾.
科学领域:
- 老年学和神经科学 在
- 生物标志物和疾病病理学
背景情况:
- 神经退行与脑血管疾病 (CVD) 相关,影响老年人的日常功能和认知健康.
- 血液生物标志物可以表明神经炎症和脑血管问题,而认知储备 (CR) 则提供了对认知衰退的保护性缓冲.
- 在发展中国家,获得构建CR的经验,如教育和复杂职业,是有限的.
研究的目的:
- 为了研究认知储备 (CR) 和特定的基于血液的生物标记物 (干白素-18,血管细胞粘附分子-1,可溶性细胞间粘附分子-1,胰腺多) 与认知有关的关系.
- 探索CR在生物标志物和认知功能之间的关联中的潜在调解作用.
主要方法:
- 来自巴拿马衰老研究倡议-健康差异研究 (PARI-HD) 的两个样本 (N=429) 的横截面分析,包括65岁以上的没有痴呆症的成年人.
- 全球认知通过迷你精神状态考试 (MMSE) 进行评估;CR使用教育,职业复杂性和日常生活工具活动 (IADL) 的综合得分计算.
主要成果:
- 观察到显著的性别和队列差异;男性通常年龄较大,职业更复杂,IL18/PPP水平更高.
- 与第2队列相比,第一队列的参与者年龄较大,受教育程度较低,独立程度较低,IL18,PPP,sVCAM1和sICAM1水平较高.
- 调解分析证实,CR调解sVCAM1和sICAM1对全球认知的影响,根据年龄,性别和队列进行调整.
结论:
- 在老年人中,神经炎症生物标志物,CR和认知功能之间存在显著的关联.
- 旨在加强CR的公共卫生政策可能会减少巴拿马等发展中国家的神经炎症相关的残疾.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations
299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis
364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations
436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management
652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies
437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437


