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通过升调FGF12表达,APC损失促进子宫内膜癌的进展:一个综合的多omics分析

Yunfeng Song¹, Cheng Zhong¹, Jian Huang¹

¹Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.

Chinese medical journal

|December 25, 2025

概括

在子宫内膜癌 (EC) 中,腺多样性大肠杆菌 (APC) 的损失促进细胞迁移,并上调纤维细胞生长因子12 (FGF12). 升高的FGF12表明预后不佳,并建议它作为EC的治疗目标.

科学领域:

在瘤学瘤学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学

背景情况:

子宫内膜癌 (EC) 是一种流行的妇科恶性瘤.
高阶染色体结构关键调节基因表达.
腺多样性大肠杆菌 (APC) 基因突变在欧洲共同体中很常见.

研究的目的:

研究APC在染色质重塑和EC进展中的作用.
确定APC损失影响EC的分子机制.
确定EC的潜在治疗目标.

主要方法:

利用癌症基因组图谱 (TCGA) 数据库进行生存分析.
进行了体外和体内实验,包括西方斑点,RT-PCR和裸体小鼠瘤发生.
进行了综合的多omics分析 (RNA-seq,ATAC-seq,Hi-C).

主要成果:

减少EC组织中的APC表达与增强的细胞迁移相关.
APC-knockdown重编程了染色质结构,上调了纤维细胞生长因子12 (FGF12).
高FGF12表达与EC患者的预后不佳有关,并且通过FGF12敲击逆转.

结论:

通过对FGF12进行上调,激活AKT和MAPK通路,APC的损失推动了EC的进展.
FGF12是EC患者低APC表达的潜在治疗标.
通过APC损失的染色体重塑影响了EC瘤发生.

关键词:

腺体多样性大肠杆菌.染色体重塑染色体重塑的方法这是子宫内膜癌的癌症.纤维细胞生长因子12 瘤迁移的过程

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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...