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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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生物标志物 生物标志物

Daehun Kang1, Paul H Min1, Seokbeen Lim1

  • 1Mayo Clinic, Rochester, MN, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
PubMed
概括
此摘要是机器生成的。

功能性MRI (fMRI) 中的呼吸触发信号 (BTS) 可以反映大脑的氧化代谢. 这项研究在轻度认知障碍 (MCI) 患者的大脑中发现了更高的BTS,这表明BTS是神经退行性疾病的潜在生物标志物.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物标志物 生物标志物
  • 认知神经科学 认知神经科学

背景情况:

  • 由于胸部运动,呼吸传统上被视为fMRI中的工件.
  • 呼吸循环会影响局部氧气度,导致BOLD信号波动.
  • 呼吸触发信号 (BTS) 可能表明潜在的脑氧代谢.

研究的目的:

  • 开发一种方法来从静止状态的fMRI中提取BTS.
  • 研究健康个体和轻度认知障碍 (MCI) 患者之间的BTS差异.

主要方法:

  • 使用一个紧的3TMRI系统进行T1加权和多回声静止状态fMRI.
  • 采用AFNI和FreeSurfer进行预处理;使用福里埃序列建模fMRI信号.
  • 应用了线性混合效应模型来分析组和呼吸周期对BTS的影响.

主要成果:

  • 观察到突出的呼吸触发的BOLD信号;心脏驱动的信号很少见.
  • 全球BTS在健康个体中显示出与呼吸周期的线性关系,甚至是物件后纠正.
  • 与健康对照人群相比,在MCI组的海马体和丘脑中发现了显著更大的BTS幅度.

结论:

  • 呼吸触发信号 (BTS) 显示出作为神经退行性疾病的非侵入性生物标志物的潜力.
  • BTS可以提供有关呼吸-脑氧代谢合的见解.
  • 由于样本规模有限,需要进一步研究,但BTS可以帮助早期检测和监测MCI.