生物标志物 生物标志物
Daehun Kang1, Paul H Min1, Seokbeen Lim1
1Mayo Clinic, Rochester, MN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
功能性MRI (fMRI) 中的呼吸触发信号 (BTS) 可以反映大脑的氧化代谢. 这项研究在轻度认知障碍 (MCI) 患者的大脑中发现了更高的BTS,这表明BTS是神经退行性疾病的潜在生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 认知神经科学 认知神经科学
背景情况:
- 由于胸部运动,呼吸传统上被视为fMRI中的工件.
- 呼吸循环会影响局部氧气度,导致BOLD信号波动.
- 呼吸触发信号 (BTS) 可能表明潜在的脑氧代谢.
研究的目的:
- 开发一种方法来从静止状态的fMRI中提取BTS.
- 研究健康个体和轻度认知障碍 (MCI) 患者之间的BTS差异.
主要方法:
- 使用一个紧的3TMRI系统进行T1加权和多回声静止状态fMRI.
- 采用AFNI和FreeSurfer进行预处理;使用福里埃序列建模fMRI信号.
- 应用了线性混合效应模型来分析组和呼吸周期对BTS的影响.
主要成果:
- 观察到突出的呼吸触发的BOLD信号;心脏驱动的信号很少见.
- 全球BTS在健康个体中显示出与呼吸周期的线性关系,甚至是物件后纠正.
- 与健康对照人群相比,在MCI组的海马体和丘脑中发现了显著更大的BTS幅度.
结论:
- 呼吸触发信号 (BTS) 显示出作为神经退行性疾病的非侵入性生物标志物的潜力.
- BTS可以提供有关呼吸-脑氧代谢合的见解.
- 由于样本规模有限,需要进一步研究,但BTS可以帮助早期检测和监测MCI.
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