用英国生物库和一项为期12周的干预研究的炼结果逆转蛋白质老化
Sindre Lee-Ødegård1,2, M Austin Argentieri3,4, Frode Norheim5
1Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
npj aging
|December 25, 2025
概括
通过蛋白质衰老得分 (ProtAgeGap) 测量的生物衰老与生活方式因素和2型糖尿病风险有关. 运动可以适度地逆转蛋白质衰老,特定的蛋白质表明代谢改善.
科学领域:
- 生物化学 生物化学
- 基因组学就是基因组学.
- 代谢学 代谢学 代谢学
背景情况:
- 生物衰老表现出个体间的变化,可能受到健康行为的影响.
- 蛋白质衰老,通过蛋白质衰老得分 (ProtAgeGap) 评估,是一种生物年龄的生物标志物.
研究的目的:
- 调查蛋白质衰老与生活方式因素之间的关联,包括体力活动和2型糖尿病风险.
- 为了确定是否监督运动可以调节蛋白质衰老和相关的代谢标志物.
主要方法:
- 在45,438名英国生物库参与者中分析蛋白质衰老得分 (ProtAgeGap).
- 对26名男性进行了为期12周的监督运动干预 (MyoGlu研究),测量了ProtAgeGap.的变化.
- 从肌肉和脂肪组织中整合转录组数据以确定分子通路.
主要成果:
- 较高的ProtAgeGap与较低的体力活动和增加2型糖尿病风险有关.
- 运动干预导致ProtAgeGap的减少,相当于老化10个月.
- 特定的蛋白质,如CLEC14A,随着运动而改变,与改善的胰岛素敏感性相关.
- 转录组数据支持蛋白质变化,涉及PI3K-Akt和MAPk信号通路.
结论:
- 蛋白质衰老是一种可修改的标志物,受到生活方式和运动的影响.
- 运动可以诱导蛋白质衰老的适度逆转,并改善代谢健康.
- 蛋白质衰老特征中的特定蛋白质可以作为代谢适应的敏感指标.
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