MAFLD增加了CKM综合征的严重程度:基于NHANES的截面研究
Alaa M Mostafa1, Yasser Fouad2, Ziayn Pan3
1Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Main Road, Minia, 11432, Egypt. alaam.mostafa2022@gmail.com.
Clinical and experimental medicine
|December 25, 2025
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加心血管--代谢 (CKM) 风险,特别是肝纤维化. 早期发现MAFLD对于CKM风险分层和干预至关重要.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 心血管--代谢 (CKM) 综合征突出显示了相关的脏和心脏代谢问题.
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 在CKM阶段化中的作用仍然不清楚.
研究的目的:
- 调查MAFLD对CKM阶段和风险的影响.
- 评估MAFLD作为高级CKM阶段的预测因素.
主要方法:
- 对6167名成年人 (18-80岁) 的NHANES数据 (2017-2020年) 的横截面分析.
- 基于AHA 2023分类的CKM分期;MAFLD和肝纤维化通过弹性学和非侵入性得分进行评估.
- 后勤回归确定了高级CKM阶段的预测因素.
主要成果:
- 92.3%的人符合CKM标准,55.1%的人患有MAFLD (CKM-MAFLD).
- CKM-MAFLD与更高的心脏代谢风险和心血管事件有关.
- MAFLD独立预测了CKM风险 (OR 1.2),由肝纤维化 (OR 1.36) 放大.
结论:
- MAFLD是CKM风险的重要预测因素,特别是在肝纤维化患者中.
- 肝脏评估对于CKM风险分层至关重要.
- 早期识别MAFLD可以在肝心轴上进行有针对性的干预.
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