用于评估SARS-CoV-2的空气传播传染性的病毒培养:系统性审查和元分析
Igho J Onakpoya1, Annette Plüddemann2, Elena C Rosca3
1Department for Continuing Education, University of Oxford, Oxford, UK. igho.onakpoya@conted.ox.ac.uk.
BMC infectious diseases
|December 25, 2025
概括
在空气样本中检测感染性SARS-CoV-2的可能性很低,即使存在病毒RNA. 这凸显了对评估空气传播病毒传播能力的标准化方法的需求.
科学领域:
- 环境病毒学 环境病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 关于空气样本中SARS-CoV-2的量化,活力和传染性存在不确定性.
- 评估空气传播的SARS-CoV-2的传染性需要高水平的确认性研究.
研究的目的:
- 系统地审查空气样本中SARS-CoV-2传染性的证据.
- 确定对SARS-CoV-2的培养阳性空气样本的比例.
主要方法:
- 在多个数据库 (LitCovid,medRxiv,PubMed,WHO Covid-19,Google Scholar) 进行了全面的文献搜索.
- 包括通过病毒培养或串行qRT-PCR评估病毒传染性的研究.
- 使用R软件进行了元分析,以汇集培养阳性空气样本的数据.
主要成果:
- 包括26项利用病毒培养进行SARS-CoV-2空气样本分析的研究.
- 阳性病毒培养的整体聚合频率为14% (95% CI 7-17%).
- 数据不足以确定传染性值或分析与距离有关的传染性.
结论:
- 阳性SARS-CoV-2病毒培养的低比例表明,与RNA存在相比,检测传染性病毒的可能性要低得多.
- 标准化指导方针对于评估和报告空气传播病毒的感染性和传染性至关重要,包括一致的Ct值报告.
- 需要进一步的研究,以减轻在评估空气传播病毒载量和传染性方面的偏见.
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