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临床表现 临床表现

Paula Aduen1, John A Lucas1, Christian Lachner1

  • 1Mayo Clinic in Florida, Jacksonville, FL, USA.

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概括
此摘要是机器生成的。

蒙特利尔认知评估 (MoCA) 等认知查工具可能错误地对美国黑人 (BA) 和西班牙裔/拉丁裔 (H/L) 成年人的认知障碍进行分类. 社会人口统计学因素显著影响表现,需要在不同的人口中仔细解释.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 公共卫生 公共卫生

背景情况:

  • 认知查工具旨在可靠地检测认知障碍.
  • 黑人美国人 (BA) 和西班牙裔/拉丁裔 (H/L) 成年人通常在这些工具上得分较低,这是由于人口统计学和健康的社会决定因素 (SSDoH).
  • 这项研究检查了蒙特利尔认知评估 (MoCA) 在多样化,认知正常的成年人中的表现,以了解错误分类因素.

研究的目的:

  • 在种族多样化,认知正常的成年人中描述MoCA的表现.
  • 确定社会人口统计学和生物学因素,有助于潜在的认知障碍错误分类.
  • 评估BA和H/L子组调整的MoCA截止值的影响.

主要方法:

  • 105名认知正常的BA和H/L参与者接受了神经评估,神经心理测试和神经成像 (MRI,粉样蛋白和tau-PET).
  • 应用了经人口统计调整的MoCA截止值:BA ≤22,H/L ≤24.
  • 层次逻辑回归分析了低MoCA分数的预测因素,包括年龄,教育,区域剥夺指数 (ADI) 和粉样蛋白负担.

主要成果:

  • 40%的H/L和17%的BA参与者得分低于人口调整后的MoCA截止值.
  • 对于H/L,年龄,教育,ADI和粉样蛋白负担,最好的预测是低MoCA分数 (R2=0.43).
  • 对于BA,年龄,教育和ADI是主要预测因素 (R2=0.47),教育接近意义.

结论:

  • 社会人口统计学因素继续影响认知正常个体的MoCA表现,即使调整了切断值.
  • 这些因素对BA/AA和WH/L参与者产生不同影响.
  • 临床和研究环境必须仔细考虑这些因素,以避免在不同人群中过度诊断认知障碍.