生物标志物 生物标志物
Tianchuan Gao1, Pradeep Varathan1, Yen-Ning Huang2,3,4,5
1Indiana university Indianapolis, Indianapolis, IN, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 25, 2025
概括
血液代谢物比率,特别是在HDL中,可以作为早期阿尔茨海默病 (AD) 的生物标志物,可能是脑脊液 (CSF) 变化之前的. 这些发现为非侵入性AD检测和监测提供了希望.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 目前阿尔茨海默病 (AD) 诊断依赖于侵入性和昂贵的脑脊液 (CSF) 生物标志物.
- 基于血液的代谢物分析为早期AD检测和监测提供了一个有希望的非侵入性替代方案.
- 反映在血液代谢物中的实时生理状态可能为早期AD病理提供了洞察力.
研究的目的:
- 为了识别在阿尔茨海默病 (AD) 中变化的血代谢物.
- 使用基于事件的歧视性建模 (DEBM) 建立血代谢物与CSF生物标志物 (Aβ42,总,酸化) 的时间序列.
- 通过纵向认知评估,验证这些代谢物作为早期AD生物标志物的有用性.
主要方法:
- 从阿尔茨海默氏病神经成像计划使用NMR光谱分析249种血代谢物.
- 应用DEBM来确定与AD相关的血液代谢物和CSF生物标志物的时间顺序.
- 纵向分析包括认知表现相关性,混合效应模型和72个月的调解分析.
主要成果:
- 在AD患者中,有8种血代谢物显著改变.
- 两种代谢物比率,特别是中等高血脂和大LDL中的脂与总脂的比率,被确定为可能与CSF Aβ42水平之前或一致.
- 在中等HDL中,高脂与总脂质比率与更好的认知功能和更慢的认知衰退有关,这表明前来CSF Aβ42变化的潜在因果途径.
结论:
- 特别的HDL脂质组成的变化可能表明AD级联的非常早期阶段,可能在CSFAβ42变化之前或同时发生.
- 中等HDL中的脂与总脂质的比率显示出作为阿尔茨海默病的非侵入性早期生物标志物的潜力.
- 在独立队列中进一步验证至关重要,以证实这些发现,并推进非侵入性AD查策略.
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