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临床表现 临床表现

Sulakshna Aggarwal1, Priya Chatterjee2, Hitesh Pradhan2

  • 1Centre for Brain Research, Bangalore, Karnataka, India.

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概括
此摘要是机器生成的。

高水平的homocysteine与较差的认知功能和较小的大脑体积在农村的印度成年人,无论维生素B12状态. 早期的homocysteine查可能有助于识别有认知能力下降风险的个体.

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科学领域:

  • 神经学 神经学
  • 营养神经科学 营养神经科学
  • 老年学是指老年学的学科.

背景情况:

  • 维生素B12影响认知功能,可能是通过同型半氨酸水平.
  • 印度农村地区对维生素B12,同类氨酸和认知/大脑健康的数据有限.

研究的目的:

  • 评估血清维生素B12,同类半氨酸,MRI脑体积和印度农村老龄化人口的认知表现之间的关联.
  • 为了研究同类氨酸在维生素B12和认知/大脑结果之间可能产生的调解作用.

主要方法:

  • 从CBR-SANSCOG队列中对2784名非痴呆症参与者 (45岁以上) 的横截面分析.
  • 使用HMSE和COGNITO电池进行认知评估;对子集的MRI脑体积 (n=1268).
  • 使用一般线性模型进行统计分析,对多种共变量进行调整.

主要成果:

  • 维生素B12水平与认知表现或大脑体积之间没有发现任何关联.
  • 较高的同类半氨酸水平与较低的HMSE和视觉注意力得分相关,并减少了海马体积.
  • 同类氨酸没有调解维生素B12和认知/大脑结果之间的关系.

结论:

  • 血清homocysteine的增加与这种人群的认知表现负面相关,独立于维生素B12水平.
  • 早期对同类氨酸的查可以识别患有认知障碍风险的个人.
  • 同类氨酸可能是用于早期认知障碍检测的多模式生物标志物的组成部分.