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临床表现 临床表现

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概括
此摘要是机器生成的。

神经精神症状 (NPS),如情感症状 (AS) 和精神错乱/激动 (PA) 影响阿尔茨海默病患者. 患病率因种族而异,早期发病的精神病更为常见.

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科学领域:

  • 神经科学是一个神经科学.
  • 老年学是指老年学的学科.
  • 精神病学是一个精神病学.

背景情况:

  • 在阿尔茨海默病 (AD) 中发表的神经精神症状 (NPS) 率表现出广泛的变化.
  • 在NPS患病率的不一致性可能源于人口统计学,临床特征和评估方法的差异.
  • 来自阿尔茨海默氏病测序项目 (ADSP) 的NPS数据的协调对于准确的流行率估计至关重要.

研究的目的:

  • 在一个大队伍中调查特定神经精神病症状表型的流行率.
  • 探索临床人口统计因素,特别是种族与NPS患病率之间的关联.
  • 为了区分早期发作和晚期发作的精神病/兴奋症状.

主要方法:

  • 利用了8项ADSP研究中的36194名参与者的数据.
  • 定义了三个NPS表型:早期 (EPA) 和晚期的精神病/兴奋 (LPA),以及情感症状 (AS).
  • 使用描述性统计和千平方分析来评估流行率和人口差异.

主要成果:

  • 影响性症状 (AS+) 在18.8%的队列中存在,精神病/兴奋 (PA+) 在5.2%的队列中存在.
  • 大多数PA+个体 (82.9%) 呈现出早期发病症状 (EPA).
  • 在AS+和PA+患病率中观察到显著的种族差异,美国印第安人/阿拉斯加土著,多种族和亚洲/太平洋岛民群体的不同模式.

结论:

  • 在总体样本中,情感症状比精神病/兴奋更为普遍.
  • 在阿尔茨海默氏症中,精神病/兴奋症状更有可能在疾病的早期过程中表现出来.
  • 观察到的NPS患病率的种族差异突显出需要对定制治疗的遗传和分子基础进行祖先特异性研究.