在使用多次每日胰岛素注射的1型糖尿病成年人糖尿病视网膜病变的预测中,狭窄范围的时间与范围的时间:用isCGM数据进行了回顾性纵向研究
Fernando Sebastian-Valles1, Elena García-Artacho2, Alberto Santiago-Redondo2
1Department of Endocrinology and Nutrition, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria de La Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
Diabetes technology & therapeutics
|December 26, 2025
概括
狭窄范围的时间 (TITR) 比范围内的时间 (TIR) 更好地预测1型糖尿病 (T1D) 中发生的糖尿病视网膜病变 (DR). 虽然TITR显示了对新DR病例的优异预测,但这两种指标同样预测了DR进展.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 代谢疾病 代谢疾病
背景情况:
- 狭窄范围内的时间 (TITR) 是比范围内的时间 (TIR) 更严格的血糖指标.
- 在1型糖尿病 (T1D) 中,TITR对糖尿病视网膜病变 (DR) 的预后价值尚未得到充分确立.
- 持续血糖监测 (CGM) 为评估糖尿病并发症提供了颗粒状血糖数据.
研究的目的:
- 评估TITR是否与TIR相比,在患有T1D的成年人中为DR提供额外的预后价值.
- 评估CGM衍生的血糖指标与DR的发病率和进展之间的关联.
- 为了确定DR结果的TITR与TIR的预测性表现.
主要方法:
- 使用CGM对309名T1D成年人的回顾性队列研究.
- 在基线和12个月后期对DR的眼科评估.
- 多变量逻辑回归分析调整为关键临床因素.
主要成果:
- 较高的TITR独立地与较低的事故DR风险相关,而TIR则不是.
- 与TIR相比,TITR在事件DR预测方面表现出更好的歧视 (AUC为0.580对0.430).
- 在预测DR进展方面,TITR和TIR都表现相似.
结论:
- 对于事件DR,TITR比TIR提供了略高的预测价值,特别是在接近目标HbA1c的个体中.
- 应与整体血糖控制和临床风险因素一起解释TITR和TIR等CGM衍生的指标.
- 需要进一步的研究,以充分阐明TITR在治疗糖尿病并发症中的作用.
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